Anthony’s Genotype

• FKBP5-CA: more receptor blocking, loss of negative feedback in HPA axis.
• NR3C2-CC: fewer receptors, loss of negative feedback in HPA axis.
• CRHR1-CC: more receptors and CRH production, stimulation of HPA axis
• COMT -GA: less clearance of stress hormones.
• CRY1- AG: blocks clock gene, decreased transition of sleep stages, increased bipolar risk.
• IL6 -GG: increased inflammation in blood vessels, joints, increased temperature.
• MMP3-TC: increased metalloproteases, joint inflammation and degradation.

Anthony’s Plan

• Sereniten Plus: 2 caps BID empty stomach one dose before bed, and 1 cap in the middle of the night to restore normal HPA function and return the NS to the PS side.
• Resveratrol Extra: 1 cap BID empty stomach to reduce IL6 and MMP3 production.
• Melatonin PR 3 mg before bed to support the blocked clock gene and help transition into stage 4 sleep quickly.
• Probio – 50B with food per day – he was already on this.
• Massage therapy every other week.
• Deep breathing – 1 minute 4 times a day.

Anthony’s Outcome

• Within 48 hours he reported feeling “like he could keep his head above water” again and more like himself.
• 2 weeks later he was sleeping 5 out of 7 nights per week, and if he woke, he was able to go back to sleep more easily.
• 3 weeks later the stress of pursuing his Masters degree started to look more like excitement, headaches and tightness in his chest alleviated
• 2 months later we reduced his supplements to 1 BID, increasing PRN.